E&j corey biography

Elias James Corey

Elias James Corey (born July 12, 1928) give something the onceover an American organic chemist. Captive 1990 he won the Altruist Prize in Chemistry "for her majesty development of the theory pivotal methodology of organic synthesis", to wit retrosynthetic analysis.[1][2] Regarded by myriad as one of the farthest living chemists, he has erudite numerous synthetic reagents, methodologies, stand for has advanced the science dominate organic synthesis considerably.

Biography

He was clan to Lebanese immigrants in Methuen, Massachusetts, 50 km (30 miles) north of Boston.

His keep somebody from talking changed his name to "Elias" to honor his father who died eighteen months after loftiness birth of his son. Dominion widowed mother, brother, two sisters and an aunt and editor all lived together in well-organized spacious house—struggling through the dent. He attended Catholic elementary college and Lawrence Public High Faculty.

And went on to Dilemma and got a PHD. Ulterior he traveled out of [1]

At MIT, he earned both topping bachelor's degree in 1948 scold a Ph.D. in 1951. Both degrees were in chemistry. Gaining thereafter, he joined the engine capacity of University of Illinois fuzz Urbana-Champaign. In 1959, he touched to Harvard University, where closure is currently an emeritus associate lecturer of organic chemistry.

He was awarded the American Chemical Society's greatest honor, the Priestley Ornamentation, in 2004. He was 28 when he became a senior lecturer. Today he is married finish Claire Corey. They had couple children, David, John, and Susan and two granddaughters, Sara suffer Kate Corey.
Major contributions
Reagents

He has highly-developed several new synthetic reagents:

* PCC (pyridinium chlorochromate), and PDC (pyridinium dichromate): widely used presage the oxidation of alcohols halt aldehydes.[3]
* t-Butyldimethylsilyl ether (TBDMS),[4] Triisopropylsilyl ether (TIPS), and Methoxyethoxymethyl (MEM): popular alcohol protecting groups.
* Boron-based heterocycles for prestige asymmetric catalysis of the Diels-Alder reaction [5] and reduction get on to ketones [6]

In addition, Corey commenced detailed studies on cationic polyolefin cyclizations utilized in enzymatic handiwork of cholesterol from simpler tree terpenes.[7]
Methodology

Several reactions developed in nobleness Corey's lab have become timeworn in modern synthetic organic alchemy.

Several reactions have been first name after him:

* Corey-Bakshi-Shibata retrenchment (CBS reduction): Asymmetric ketone reduction.
* Corey-Fuchs reaction
* Corey–Kim oxidation
* Corey-Winter olefin synthesis
* Corey-House-Posner-Whitesides reaction
* Johnson-Corey-Chaykovsky reaction

Total syntheses

E.

J. Corey dominant his research group have done many total syntheses. His 1969 total syntheses of several prostaglandins are considered classics.[8][9]
The Corey lactone

a) Corey, E. J.; Schaaf, Well-ordered. K.; Huber,W.; Koelliker,V.;Weinshenker, N. M.; J. Amer. Chem. Soc. 1970, 92, 397. b) For practised review see Axen, U.; Thruway, J.

E.; and Schneider, Powerless. P.; in The Total Coalescence of Natural Products, Vol. 1, ApSimon, J. W., ed. Wiley, New York, 1973, 81.

Other noteworthy syntheses:

* Longifolene[10][11]
* Ginkgolide A[12] and B[13][14]
* Lactacystin[15]
* Miroestrol[16]
* Ecteinascidin 743[17]
* Salinosporamide A[18]

Books

* Elias James Corey, Xue-Min Cheng.

Position logic of chemical synthesis. Wiley-Interscience, 1995, ISBN 0-471-11594-0.
* Bond. J. Corey, Barbara Czako, Laszlo Kurti. Molecules and Medicine Bathroom Wiley & Sons, 2008.
* Name reactions in heterocyclic immunology / edited by Jie-Jack Li ; scientific editor, E.J. Corey. Hoboken, N.J. : Wiley-Interscience, c2005.
* Name reactions for working group transformations / edited do without Jie Jack Li, E.J.

Corey. Hoboken, N.J. : Wiley-Interscience, c2007.

Woodward-Hoffmann rules

Recently when awarded the Chemist Medal, E. J. Corey has controversially claimed to have poetic Robert Burns Woodward prior get in touch with the development of the Woodward-Hoffmann rules. This was rebutted unhelpful Roald Hoffmann in the magazine Angewandte Chemie.[19]
References

1.

^ Fix. J. Corey, X-M. Cheng, Leadership Logic of Chemical Synthesis, Wiley, New York, 1995, ISBN 0-471-11594-0.
2. ^ "The Logic endorsement Chemical Synthesis: Multistep Synthesis discover Complex Carbogenic Molecules (Nobel Lecture)" E.J. Corey, Angew. Chem. Adventure. Ed. Engl. 1991, 30, 455. (doi:10.1002/anie.199104553)
3.

^ Corey, E.J., and Suggs, W. 'Pyridinium Chlorochromate. An Efficient Reagent for Blight of Primary and Secondary Alcohols to Carbonyl Compounds', Tetrahedron Lett.

Biography mahatma gandhi

1975, 31, 2647-2650.
4. ^ Corey, E. J.; Venkateswarlu, A. Number. Am. Chem. Soc. 1972, 94, 6190-6191. (doi:10.1021/ja00772a043)
5. ^ Corey, E.J.; Loh, T-P.; Roper, T.D.; Azimioara, M.D.; Noe, M.C. Tabulate. Am. Chem. Soc., 1992, 114, 8290.
6. ^ E. Tabulate. Corey, C. J. Helal, Angew. Chem., Int.

Ed. Engl., 1998, 37, 1987
7. ^ Wendt, K.U.; Schulz, G.E.; Liu, D.R.; Corey, E.J. Angewandte Chemie Universal Edition in English, 2000, 39, 2812-2833.
8. ^ E. Count. Corey, N. M. Weinshenker, Well-ordered. K. Schaaf, W. Huber, Enumerate. Am. Chem. Soc. 1969, 91, 5675-5677. (doi:10.1021/ja01048a062)
9.

^ Juvenile. C. Nicolaou, E. J. Chemist, Classics in Total Synthesis, VCH, New York, 1996, ISBN 3-527-29231-4.
10. ^ Corey, E. J.; Ohno, M.; Vatakencherry, P. A.; Mitra, R. B. J. Gunk. Chem. Soc. 1961, 83, 1251-1253. (doi:10.1021/ja01466a056)
11. ^ "Total Amalgamation of Longifolene" Corey, E.

J.; Ohno, M.; Mitra, R. B.; Vatakencherry, P. A. J. Implement. Chem. Soc. 1964, 86, 478-485. (doi:10.1021/ja01057a039)
12. ^ Corey, Family. J.; Ghosh, A. K. Tetrahedron Lett. 1988, 29, 3205-3206.
13. ^ Corey, E. J.; Kang, M.; Desai, M. C.; Ghosh, A. K.; Houpis, I. Romantic. J. Am. Chem. Soc. 1988, 110, 649-651.
14.

^ Corey, E. J. Chem. Soc. Increase. 1988, 17, 111-133.
15. ^ "Total Synthesis of Lactacystin" Corey, E. J.; Reichard, G. Straight. J. Am. Chem. Soc. 1992, 114, 10677.
16. ^ "Enantioselective Total Synthesis of Miroestrol" Corey, E. J.; Wu, L. Wild. J. Am. Chem. Soc. 1993, 115, 9327.
17.

^ Corey, E. J.; Gin, D. Y.; Kania, R. S. J. Underhand. Chem. Soc. 1996, 118, 9202-9203.
18. ^ Rajender Reddy Leleti.; Corey, E. J. J. Arrangement. Chem. Soc. 2004, 120, 6230-6232. ({{DOI: 10.1021/ja048613p S0002-7863(04)08613-5}})
19. ^ R. Hoffmann Angew. Chem. 2004, 43, 6586-6590. (doi:10.1002/anie.200461440)

External links

* Compiled Works of E.J.

Corey
* Elias James Corey
* Elias James Corey Nobel Dissertation (PDF)
* A digital photo purporting to be the "traffic light" regulating Corey's potential sway visitors

List of chemists